General description Moclobemide is a selective and reversible monoamine oxidase A (MAO‑A) inhibitor (RIMA). By inhibiting MAO‑A, and to a lesser extent MAO‑B, it increases levels of serotonin and norepinephrine and, to a smaller degree, dopamine in the central nervous system. Because its binding to MAO‑A is reversible, tyramine can displace moclobemide from the enzyme, … Read more
MAOIs (Monoamine oxidase inhibitors) GENERAL DESCRIPTION MAOIs were the first class of drugs that have antidepressant effects. They may be classified as hydrazide chemically. Now these drugs have been little use because of their toxicity and lethal drug-food and drug-drug interaction. Isocarboxazid, phenelzine, tranylcypromine which are all irreversible inhibitors of both MAO A and MAO … Read more
VENLAFAXINE GENERAL DESCRIPTION Venlafaxine is the first SNRIs that is used commonly in depression and anxiety disorders. Venlafaxine is a potent inhibitor of serotonin transporter and a weak norepinephrine transport. At low doses it behaves same as SSRIs but at high doses it increase blood pressure and heart rate. GENERIC NAME: Venlafaxine BRAND NAME: Effexor … Read more
SNRIs (Serotonin Norepinephrine reuptake inhibitors) GENERAL DESCRIPTION SNRIs are antidepressants which work by inhibiting both serotonin and norepinephrine reuptake transporter. SNRIs are the most prescribed antidepressants now a days. Class Generic Name Brand Name SNRIs (Serotonin nor epinephrine reuptake inhibitors) Venlafaxine Effexor Desvenlafaxine Desfax, Pristiq, Ellefore Duloxetine Cymbalta Levomilnacipran Fetzima … Read more
GENERAL DESCRIPTION Fluoxetine is an antidepressant and classified in serotonin reuptake inhibitors (SSRIs). Fluoxetine was the first SSRI to reach general clinical use. GENERIC NAME: Fluoxetine BRAND NAME: Prozac MECHANISM OF ACTION Fluoxetine work by elevating serotonin neurotransmitter in the brain. At presynaptic serotonergic neuron, this interact with postsynaptic neuron which have postsynaptic receptors which … Read more
SSRIs (Selective serotonin reuptake inhibitors) GENERAL DESCRIPTION SSRIs are the drugs used as antidepressants. SSRIs are usually the first choice of treatment for depression because of fewer side effects than other class of antidepressants. SSRIs are generally free of sedative effects and safe in overdose. Class Generic Name Brand Name SSRIs … Read more
GENERAL DESCRIPTION Major depression and anxiety is the most common psychiatric disorder. At any given moment 3-5% of the population is depressed. The symptoms of depression are often indirect or unrecognized both by patients and by physicians. Depression is a heterogeneous disorder that has been classified in a number of ways. Drugs used to treat … Read more
SODIUM NITROPRUSSIDE: MIX VASODILATOR GENERAL DESCRIPTION Sodium Nitroprusside is a complex of iron, cyanide groups, and a nitroso moiety. It is also known as glyceryl nitrate (GTN). It is a powerful parenterally administered nitro vasodilator. It dilates both arterial and venous vessels unlike other nitrates. GENERIC NAME: Sodium nitroprusside BRAND NAME: Nitropress MECHANISM OF ACTION Nitrodilators … Read more
HYDRALAZINE: ARTERIAL VASODILATOR GENERAL DESCRIPTION Hydralazine is a hydrazine derivatives and is a direct acting vasodilator. It dilates arterioles but not veins. Hydralazine is effectively used in combination therapy for severe hypertension. Hydralazine is used as a hypertensive emergency. GENERIC NAME: Hydralazine BRAND NAME: Apresoline MECHANISM OF ACTION Hydralazine is direct acting vasodilators. It is … Read more
NITROGLYCERIN: VENOUS VASODILATOR (ORGANIC NITRATES) GENERAL DESCRIPTION Nitroglycerin is also known as glyceryl nitrates (GTN). It is a nitrodilators. Nitroglycerin is the prototype of nitrodilators. Sublingual nitroglycerin is the most frequently used agent for the immediate treatment of angina. GENERIC NAME: Glyceryl nitrate BRAND NAME: Nitrostat, Nitro-bid, Nitro-quick MECHANISM OF ACTION Nitrodilators are divided into … Read more